Klinične značilnosti odraslih bolnikov z multiplo sklerozo
presečna raziskava
DOI:
https://doi.org/10.14528/snr.2020.54.2.3016Ključne besede:
multipla skleroza, kakovost življenja, nevrološka prizadetost, funkcionalne sposobnostiPovzetek
Uvod: Namen raziskave je bil ugotoviti morebitne povezave med kakovostjo življenja, nevrološko prizadetostjo in funkcionalnimi zmožnostmi pri bolnikih z multiplo sklerozo.
Metode: V presečno raziskavo je bilo vključenih 258 pacientov z multiplo sklerozo. Ocenjeni so bili s pomočjo Expanded Disability Status Scale (EDSS), Berg Balance Scale (BBS), Timed 25-Foot Walk Test (T25-FW), 9-Hole Peg Test (9HPT), Paced Auditory Serial Addition Test (PASAT-3) in lestvice EQ visual analogue scale (EQ-VAS). Uporabljena je bila inferenčna statistika.
Rezultati: Pokazala se je pozitivna povezava med oceno EQ-VAS ter BBS (r = 0,43, p < 0,01) in PASAT-3 (r = 0,19, p < 0,01) in negativna povezava med EQ-VAS ter T25FW (r = –0,42, p < 0,01) in 9-HPT (r = –0,40, p < 0,01). Negativne korelacije smo zaznali tudi med oceno EDSS in BBS (r = –0,77, p < 0,05) ter PASAT-3 (r = –0,25, p < 0,01), pozitivne povezave pa med EDSS in 9 HPT (r = 0,67, p < 0,01) ter T25-FW (r = 0,80, p < 0,01).
Diskusija in zaključek: Povezave med navedenimi spremenljivkami kažejo na potrebo po kompleksnem, personaliziranem in racionalnem spremljanju pacientov z multiplo sklerozo.
Prenosi
Metrike
Literatura
Amato, M.P. & Portaccio, E., 2007. Clinical outcome measures in multiple sclerosis. Journal of the Neurological Sciences, 259(1/2), pp. 118–122. https://doi.org/10.1016/j.jns.2006.06.031 PMid:17376487
Atteya, A., Elwishy, A., Kishk, N., Ismail, S.R. & Badawy, R., 2019. Assessment of postural balance in multiple sclerosis patients. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 55(7), pp. 1–5. https://doi.org/10.1186/s41983-018-0049-4
Baumstarck-Barrau, K., Simeoni, M.C., Reuter, F., Klemina, I., Aghababian, V., Pelletier, J., et al., 2011. Cognitive function and quality of life in multiple sclerosis patients: a cross-sectional study. BMC Neurology, 11(17), pp. 1–10. https://doi.org/10.1186/1471-2377-11-17 PMid:1288343; PMCid:PMC3039581
Berg, K., Wood-Dauphinee, S., Williams, J.I. & Gayton, D., 1989. Measuring balance in the elderly: preliminary development of an instrument. Physiotherapy Canada, 41(6), pp. 304–311. https://doi.org/10.3138/ptc.41.6.304
Bethoux, F.A., Palfy, D.M. & Plow M.A., 2016. Correlates of the timed 25 foot walk in a multiple sclerosis outpatient rehabilitation clinic. International Journal of Rehabilitation Research, 39(2), pp. 134–139. https://doi.org/10.1097/MRR.0000000000000157 PMid:26926380; PMCid:PMC4850097
Cohen, J.A., Reingold, S.C., Polman, C.H., Wolinsky, J.S. & International Advisory Committee on Clinical Trials in Multiple Sclerosis, 2012. Disability outcome measures in multiple sclerosis clinical trials: current status and future prospects. Lacent Neurology, 11(5), pp. 467–476. https://doi.org/10.1016/S1474-4422(12)70059-5
Cutter, G.R., Baier, M.L., Rudick, R.A., Cookfair, D.L., Fischer, J.S., Petkau, J., et al., 1999. Development of a multiple sclerosis functional composite as a clinical trial outcome measure. Brain, 122(5), pp. 871–882. https://doi.org/10.1093/brain/122.5.871 PMid:10355672
EuroQol Group, 2017. EQ-5D-3L /About. Rotterdam: EuroQol Group. Available at: https://euroqol.org/eq-5d-instruments/eq-5d-3l-about/ [11. 11. 2019].
European Multiple Sclerosis Platform & Rehabilitation in Multiple Sclerosis, 2012. Recommendations on rehabilitation services for persons with Multiple Sclerosis in Europe. Brussels: European Multiple Sclerosis Platform, p. 59. Available at: http://www.emsp.org/wp-Content/uploads/2015/11/12-0431_Henze-30-04-12.pdf [6. 7. 2019].
Feys, P., Lamers, I., Francis, G., Benedict, R., Phillips, G.,LaRocca, N., et al., 2017. The Nine-Hole Peg Test as a manual dexterity performance measure for multiple sclerosis. Multiple Sclerosis Journal, 23(5), pp. 711–720. https://doi.org/10.1177/1352458517690824 PMid:28206826; PMCid:PMC5405844
Fischer, J.S, Jak, A.J., Kniker, J.E., Rudick, R.A. & Cutter, G., 2001. Multiple Sclerosis Functional Composite (MSFC). Administration and scoring manual. National Multiple Sclerosis Society, pp. 1–44. Available at: http://main.nationalmssociety.org/docs/HOM/MSFC_Manual_and_Forms.pdf [16. 11. 2019].
Fjeldstad-Pardo, C., Pardo, G., Frederiksen, C., Bemben, D.A. & Bemben, M., 2009. Assessment of postural balance in multiple sclerosis. International Journal of MS Care, 11, pp. 1–5. https://doi.org/10.7224/1537-2073-11.1.1
Goldman, M.D., Motl, R.W. & Rudick, R.A., 2010. Possible clinical outcome measures for clinical trials in patients with multiple sclerosis. Therapeutic Advances in Neurological Disorders, 3(4), pp. 229–239. https://doi.org/10.1177/1756285610374117 PMid:21179614; PMCid:PMC3002657
Højsgaard Chow, H., Schreiber, K., Magyari, M., Ammitzbøll, C., Börnsen, L., Romme Christensen, J., et al., 2018. Progressive multiple sclerosis, cognitive function, and quality of life. Brain and Behavior, 8(2), pp. 1–7. https://doi.org/10.1002/brb3.875 PMid:29484253; PMCid:PMC5822575
Hutchinson, B., Forwell, S.J., Bennett, S., Brown, T., Karpatkin, H. & Miller, D., 2009. Toward a consensus on rehabilitation outcomes in MS: gait and fatigue. Report of a CMSC Consensus Conference, November 28-29, 2007. International Journal of MS Care, 11, pp. 67–78. https://doi.org/10.7224/1537-2073-11.2.67
Jones, K.H., Ford, D.V., Jones, P.A., John, A., Middelton, R.M., Lackhart Jones, H., et al., 2013. How people with multiple sclerosis rate their quality of life: an EQ-5D survey via the UK MS Register. PLoS One, 8(6), pp. 1–8. https://doi.org/10.1371/journal.pone.0065640 PMid:23776516; PMCid:PMC36791547
Karabudak, R., Dahdaleh, M., Aljumah, M., Alroughani, R., Alsharoqi, I.A., AlTahan, A.M., et al., 2015. Functional clinical outcomes in multiple Sclerosis: current status and future prospects. Multiple Sclerosis and Related Disorders, 4(3), pp. 192–201. https://doi.org/10.1016/j.msard.2015.03.004 PMid:26008936
Kieseier, B.C. & Pozzilli, C., 2012. Assessing walking disability in multiple sclerosis. Multiple Sclerosis Journal, 18(7), pp. 914–924. https://doi.org/10.1177/1352458512444498 PMid:22740603
Kurtzke, J.F., 1983. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology, 33(11), pp. 1444–1452. https://doi.org/10.1212/WNL.33.11.1444 PMid:6685237
Łabuz Roszak, B., Kubicka-Bączyk, K., Pierzchała, K., Horyniecki, M., Machowska-Majchrzak, A., Augustyńska-Mutryn, D., et al., 2013. Quality of life in multiple sclerosis – association with clinical features, fatigue and depressive syndrome. Psychiatria Polska, 47(3), pp. 433–441.
Lysandropoulos, A.P. & Havrdova, E., 2015. 'Hidden' factors influencing quality of life in patients with multiple sclerosis. European Journal of Neurology, 22(Suppl 2), pp. 28–33. https://doi.org/10.1111/ene.12801 PMid:26374511
Matias-Guiu, J.A., Cortés-Martínez, A., Valles-Salgado, M., Oreja-Guevara, C., Pytel, V. & Montero, P., 2017. Functional components of cognitive impairment in multiple sclerosis: a cross-sectional investigation. Frontiers in Neurology, 8(643), pp. 1–9. https://doi.org/10.3389/fneur.2017.00643 PMid:29234305; PMCid:PMC5712315
Meyer-Moock, S., Feng, Y.S., Maeurer, M., Dippel, F.W. & Kohlmann, T., 2014. Systematic literature review and validity evaluation of the Expanded Disability Status Scale (EDSS) and the Multiple Sclerosis Functional Composite (MSFC) in patients with multiple sclerosis. BMC Neurology, 14(58), pp. 1–10. https://doi.org/10.1186/1471-2377-14-58 PMid:24666846; PMCid:PMC3986942
Motl, R.W., Cohen, J.A., Benedict, R., Phillips, G., LaRocca, N., Hudson, L.D., et al., 2017. Validity of the timed 25-foot walk as an ambulatory performance outcome measure for multiple sclerosis. Multiple Sclerosis Journal, 23(5), pp. 704–710. https://doi.org/10.1177/1352458517690823 PMid:28206828; PMCid:PMC5405807
National Multiple Sclerosis Society, 2019. Paced Auditory Serial Addition Test (PASAT). Available at: https://www.nationalmssociety.org/For-Professionals/Researchers/Resources-for-Researchers/Clinical-Study-Measures/Paced-Auditory-Serial-Addition-Test-(PASAT) [12. 11. 2019].
Nowinski, C.J., Miller, D.M. & Cella, D., 2017. Evolution of patient-reported outcomes and their role in multiple sclerosis clinical trials. Neurotherapeutics, 14, pp. 934–944. https://doi.org/10.1007/s13311-017-0571-6 PMid:28913785; PMCid:PMC5722775
Opara, J.A., Jaracz, K. & Brola, W., 2010. Quality of life in multiple sclerosis. Journal of Medicine and Life, 3(4),pp. 352–358.
Ozakbas, S., Cagiran, I., Ormeci, B. & Idiman, E., 2004. Correlations between multiple sclerosis functional composite, expanded disability status scale and health-related quality of life during and after treatment of relapses in patients with multiple sclerosis. Journal of the Neurological Sciences, 218(1/2), pp. 3–7. https://doi.org/10.1016/j.jns.2003.09.015 PMid:14759626
Ozakbas, S., Turkoglu, R., Tamam, Y., Terzi, M., Taskapilioglu, O., Yucesan, C., et al., 2018. Prevalence of and risk factors for cognitive impairment in patients with relapsing-remitting multiple sclerosis: multi-center, controlled trial. Multiple Sclerosis and Related Disorders, 22(2018), pp. 70–76. https://doi.org/10.1016/j.msard.2018.03.009 PMid:29605801
Papuć, E. & Stelmasiak, Z., 2012. Factors predicting quality of life in a group of Polish subjects with multiple sclerosis: accounting for functional state, socio-demographic and clinical factors. Clinical Neurology and Neurosurgery, 114(4), pp. 341–346. https://doi.org/10.1016/j.clineuro.2011.11.012 PMid:22137087
Piri Çinar, B. & Güven Yorgun, Y., 2018. What we learned from the history of multiple sclerosis measurement: expanded disability status scale. Archives of Neuropsychiatry, 55(Suppl 1), pp. 69–75. https://doi.org/10.29399/npa.23343 PMid:30692861; PMCid:PMC6278618
Prosperini, L. & Castelli, L., 2018. Spotlight on postural control in patients with multiple sclerosis. Degenerative Neurological and Neuromuscular Disease, 8, pp. 25–34. https://doi.org/10.2147/DNND.S135755 PMid:30050386; PMCid:PMC6053902
Reese, J.P., Wienemann, G., John, A., Linnemann, A., Balzer- Geldsetzer, M., Mueller, U.O., et al., 2013. Preference-based health status in a German outpatient cohort with multiple sclerosis. Health and Quality of Life Outcomes, 11(162), pp. 1–9. https://doi.org/10.1186/1477-7525-11-162 PMid:24089999; PMCid:PMC3851447
Rugelj, D. & Palma, P., 2013. Bergova lestvica za oceno ravnotežja. Berg balance scale. Fizioterapija, 21(1), pp. 15–25.
Shapiro, R.T., 2011. Best practices in comprehensive MS symptomatic management. Reports from a CMSC Consensus Conference: team approach to complex symptomatic management in multiple sclerosis. International Journal of MS Care, 13(Suppl 4), p. 12. https://doi.org/10.7224/1537-2073-13.S4.1 PMid:24453699; PMCid:PMC3882948
Slavkovic, S., Golubovic, S., Vojnovic, M. & Nadj, C., 2019. Influence of cognitive and motor abilities on the level of current functioning in people with multiple sclerosis. Zdravstveno Varstvo, 58(2), pp. 54–61. https://doi.org/10.2478/sjph-2019-0007 PMid:30984295; PMCid:PMC6455014
Tiftikçioğlu, B.I., 2018. Multiple Sclerosis Functional Composite (MSFC): scoring instructions. Archives of Neuropsychiatry, 55(Suppl 1), pp. S46–S48. https://doi.org/10.29399/npa.23330
van Winsen, L.M.L., Kragt, J.J., Hoogervorst, E.L.J., Polman, C.H. & Uitdehaag, B.M.J., 2010. Outcome measurement in multiple sclerosis: detection of clinicaly relevant improvement. Multiple Sclerosis, 16(5), pp. 604–610. https://doi.org/10.1177/1352458509359922 PMid:20086019
Yalachkov, Y., Soydas, D., Bergmann, J., Frisch, S., Behrens, M., Foerch, et al., J. 2019. Determinants of quality of life in relapsing-remitting and progressive multiple sclerosis. Multiple Sclerosis and Related Disorders, 30, pp. 33–37. https://doi.org/10.1016/j.msard.2019.01.049 PMid:30735970
Ysrraelit, M.C., Fiol, M.P., Gaitán, M.I. & Correale, J., 2018. Quality of life assessment in multiple sclerosis: different perception between patients and neurologists. Frontiers in Neurology, 8(729), pp. 1–6. https://doi.org/10.3389/fneur.2017.00729 PMid:29375468; PMCid:PMC5769192
Prenosi
Objavljeno
Kako citirati
Številka
Rubrike
Licenca
Na Obzornik zdravstvene nege, Ob železnici 30A, 1000 Ljubljana, prenašam naslednje materialne avtorske pravice: pravico reproduciranja v neomejeni količini, in sicer v vseh poznanih oblikah reproduciranja, kar obsega tudi pravico shranitve in reproduciranja v kakršnikoli elektronski obliki (23. čl. Zakona o avtorski in sorodnih pravicah – v nadaljevanju ZASP); pravico distribuiranja (24. čl. ZASP); pravico dajanja na voljo javnosti vključno z dajanjem na voljo javnosti prek svetovnega spleta oz. računalniške mreže (32.a čl. ZASP); pravico predelave, zlasti za namen prevoda (33. čl. ZASP). Prenos pravic velja za članek v celoti (vključno s slikami, razpredelnicami in morebitnimi prilogami). Prenos je izključen ter prostorsko in časovno neomejen.