Raba konoplje v medicinske namene

integrativni pregled literature

Avtorji

  • Armin Čulić Univerzitetna psihiatrična klinika Ljubljana, Grablovičeva ulica 48, 1000 Ljubljana, Slovenija https://orcid.org/0000-0002-8290-8930
  • Branko Bregar Univerzitetna psihiatrična klinika Ljubljana, Studenec 48, 1260 Ljubljana Polje, in Fakulteta za zdravstvo Angele Boškin, Spodnji Plavž 3, 4270 Jesenice, Slovenija https://orcid.org/0000-0002-2341-2732
  • Mirna Macur Fakulteta za zdravstvo Angele Boškin, Spodnji Plavž 3, 4270 Jesenice, Slovenija

DOI:

https://doi.org/10.14528/snr.2021.55.4.3063

Ključne besede:

kanabis, medicinska raba, zdravljenje

Povzetek

Uvod: Slovenija je leta 2017 spremenila uredbo o razvrstitvi prepovedanih drog in omogočila uporabo konoplje v medicinske namene. Konoplja ima več kot 140 kanabinoidnih spojin, med katerimi sta najbolj izpostavljeni kanabidiol in tetrahidrokanabinol, saj imata potencial za zdravljenje bolezni. Namen pregleda je raziskati rabo konoplje v medicinske namene.
Metode: Izveden je bil integrativni pregled literature v digitalni zbirki podatkov PubMed, spletnem iskalniku Google učenjak in vzajemnemu bibliografskemu sistemu COBISS s pomočjo besednih zvez: »cannabis AND medical use«, »marihuana AND medical use« in »raba konoplje v medicinske namene«. Omejitve iskanja so bile: obdobje objave literature (2008–2019), prost dostop do recenziranih strokovnih in znanstvenih člankov ter literatura v angleškem ali slovenskem jeziku. Za pregled literature je bila uporabljena tematska analiza prebranega gradiva.
Rezultati: Za pregled literature je bilo za končno analizo primernih 29 člankov. Identificiranih je bilo 52 kod, združenih v štiri teme: (1) zdravljenje s konopljo, (2) lastnosti konoplje, (3) delovanje kanabidiola, (4) delovanje tetrahidrokanabinola.
Diskusija in zaključek: Konoplja se že tisočletja uporablja v medicinske namene. Danes jo v svetu uporabljajo predvsem za zdravljenje naslednjih bolezni: astme, diabetesa, epilepsije, raka, Parkinsonove bolezni, Alzheimerjeve demence, multiple skleroze. V Sloveniji je konoplja odstranjena s seznama najbolj nevarnih drog, a do njene rabe v medicinske namene je zahteven proces.

Prenosi

Podatki o prenosih še niso na voljo.

Metrike

Nalaganej metrik....

Literatura

Abramovici, H. (2013). Information for health care proffessionals, cannabis (marihuana, marijuana) and the cannabinoids. Ottawa: Health Canada.

Aveyard, H. (2018). Doing a literature review in health and social care: A practical guide. London: McGraw-Hill Education.

Atakan, Z. (2012). Cannabis, a complex plant: Different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology, 2(6), 241–254. https://doi.org/10.1177/2045125312457586 PMid:23983983; PMCid:PMC3736954 DOI: https://doi.org/10.1177/2045125312457586

Baron, E. P. (2015). Comprehensive review of medicinal marijuana, cannabinoids and therapeutic implications in medicine and headache: What a long strange trip it's been. Headache, 55(6), 885–916. https://doi.org/10.1111/head.12570 PMid:26015168 DOI: https://doi.org/10.1111/head.12570

Bellnier, T., Brown, G. W., & Ortega, T. R. (2018). Preliminary evaluation of the efficacy, safety and costs associated with the treatment of chronic pain with medical cannabis. Mental Health Clinician, 8(3), 110–115. https://doi.org/10.9740/mhc.2018.05.110 PMid:29955555; PMCid:PMC6007634 DOI: https://doi.org/10.9740/mhc.2018.05.110

Bonnet, U., & Preuss, U. W. (2017). The cannabis withdrawal syndrom: Current insights. Substance Abuse and Rehabilitation, 8, 9–37. https://doi.org/10.2147/SAR.S109576 PMid:28490916; PMCid:PMC5414724 DOI: https://doi.org/10.2147/SAR.S109576

Borgelt, L. M., Franson, K. L., Nussbaum, A. M., & Wang, G. S. (2013). The Pharmacologic and Clinical Effects of Medical Cannabis, 33(2), 195–209. https://doi.org/10.1002/phar.1187 PMid:23386598 DOI: https://doi.org/10.1002/phar.1187

Bučan, E., & Bregar, B. (2017). Uporaba novih psihoaktivnih snovi med študenti zdravstvenih in pedagoških poklicev. Obzornik zdravstvene nege, 51(1), 42–51. https://doi.org/10.14528/snr.2017.51.1.109 DOI: https://doi.org/10.14528/snr.2017.51.1.109

Budney, A. J., & Borodovsky, J. T. (2017). The potential impact of cannabis legalization on the development of cannabis use disorders. Preventive Medicine, 104, 31–36. https://doi.org/10.1016/j.ypmed.2017.06.034 PMid:28668544; PMCid:PMC5735001 DOI: https://doi.org/10.1016/j.ypmed.2017.06.034

Colbert, M. (2015). Indica, sativa, ruderalis: Did we get it all wrong. Retrieved May 6, 2021 from http://theleafonline.com/c/ science/2015/01/indica-sativa-ruderalis-get-wrong

Corey-Bloom, J., Wolfson, T., Gamst, A., Jin, S., Marcotte, T.D., Bentley, H., & Gouaux, B. (2012). Smoked cannabis for spasticity in multiple sclerosis: A randomized, placebocontrolled trial. Canadian Medical Association Journal, 184(10), 1143–1150. https://doi.org/10.1503/cmaj.110837 PMid:22586334; PMCid:PMC3394820 DOI: https://doi.org/10.1503/cmaj.110837

Crippa, J. A., Guimarães, F. S., Campos, A. C., & Zuardi, A. W. (2009). Translational investigation of the therapeutic potential of cannabidiol: Toward a new age. Frontiers in Immunology, 9, 33–89. https://doi.org/10.3389/fimmu.2018.02009 PMid:30298064; PMCid:PMC6161644 DOI: https://doi.org/10.3389/fimmu.2018.02009

Čanji, P. (2018). Konoplja in kanabinoidi: pozitivna pridobitev ali prikrito zlo. Celje: Mestna občina Celje, Mladi za Celje. Retrieved October 31, 2019 from https://www.knjiznica-celje.si/raziskovalne/4201803590.pdf

Dariš, B., Tancer Verboten, M., Knez, Ž., & Ferk, P. (2018). Cannabinoids in cancer treatment: Therapeutic potential and legislation. Bosnian Journal of Basical Medical Sciences, 19(1), 14–23. https://doi.org/10.17305/bjbms.2018.3532 PMid:30172249; PMCid:PMC6387667 DOI: https://doi.org/10.17305/bjbms.2018.3532

Dremelj, Z., Kastelic, A., & Kostnapfel Rihtar, T. (2012). Testiranje na prisotnost prepovedanih psihoaktivnih snovi. Ljubljana: Prohealth.

Ferjan, I., Kržan, M., Lipnik-Štangelj, M., Žiberna, L., Stanovnik, L., & Černe, K. (2015). Farmakologija kanabinoidov. Zdravstveni Vestnik, 84(6), 456–471. https://doi.org/10.6016/ZdravVestn.1360 DOI: https://doi.org/10.6016/ZdravVestn.1360

Hancox, R. J., Shin, H. H., Gray, A. R., Poulton, R., & Sears, M. R. (2015). Effects of quitting cannabis on respiratory symptoms. European Respiratory Society, 46(1), 80−87. https://doi.org/10.1183/09031936.00228914 PMid:25837035; PMCid:PMC4780250 DOI: https://doi.org/10.1183/09031936.00228914

Herenda, D. (2017). Predlog sprememb in dopolnitev ZPrCP. Ljubljana: Nacionalni center za upravljanje prometa. Retrieved January 14, 2019 from http://odborzakonopljo.si/wp-content/ uploads/2017/12/Predlog-sprememb-in-doplonitev-ZPrCPNCUP.pdf

Hren, J., & Belščak, A. (2017). Drug policy workbook. In A. Drev, A. Hočevar Grom & A. Belščak (Eds.), Report on the Drug Situation 2017 of the Republic of Slovenia. Ljubljana: Nacionalni inštitut za javno zdravje.

King, L. A. (2004). An overview of cannabis potency in Europe. Luxembourg: Office for Official Publications of the European Communities.

Ko, G. D., Bober, S., Mindra, S., & Moreau, J. M. (2016). Medical cannabis: The Canadian perspective. Journal of Pain Research, 9, 735–744. https://doi.org/10.2147/JPR.S98182 PMid:27757048; PMCid:PMC5053383 DOI: https://doi.org/10.2147/JPR.S98182

Koprivnikar, H., Zupanič, T., Drev, A. & Jeriček Klanšček, H. (2019). Prevalence and characteristics of tobacco and cannabis co-use in 15 year-old students in Slovenia. Obzornik zdravstvene nege, 53(2), 104–111. https://doi.org/10.14528/snr.2019.53.1.259 DOI: https://doi.org/10.14528/snr.2019.53.1.259

Jacobson, C., & Porter, B. E. (2013). Survey of currennt cannabidiol use in pediatric treatment: Resistant epilepsy. Department of Neurology, Stanford University. Retrieved April 5, 2019 from: https://www.thcint.com/uploads/1/9/3/7/19371199/cannabidiol_ use_in_pediatric_epilepsy.pdf

Lochte, B., Beletsky, A., Samuel, N., & Grant, I. (2017). The use of cannabis for headache disorders. Cannabis and Cannabinoid Research, 2(1), 61–71. https://doi.org/10.1089/can.2016.0033 PMid:28861505; PMCid:PMC5436334 DOI: https://doi.org/10.1089/can.2016.0033

Marshall, K., Gowing, L., Ali, R., & Le Foll, B. (2014). Pharmacotherapies for cannabis dependence. Cochrane Database System reviews. https://doi.org/10.1002/14651858.CD008940.pub2 PMid:25515775; PMCid:PMC4297244 DOI: https://doi.org/10.1002/14651858.CD008940.pub2

Martell, K., Fairdchild, A., LeGerrier, B., Sinha, R., Baker, S., Liu, H. … Kerba, M. (2018). Rates of cannabis use in patients with cancer. Current Oncology, 25(3), 219–225. https://doi.org/10.3747/co.25.3983 PMid:29962840; PMCid:PMC6023560 DOI: https://doi.org/10.3747/co.25.3983

Meier, M., Caspi, A., Cerdá, M., Hancox, R. J., Harrington, H., Houts, R. … Moffitt, T.E. (2017). Associations between cannabis use and physical health problems in early midlife: A longitudinal comparison of persistent cananbis versus tobacco users. The journal of the American Medical Association Psychiatry, 73(7), 731–740. https://doi.org/10.1001/jamapsychiatry.2016.0637 PMid:27249330; PMCid:PMC4936934 DOI: https://doi.org/10.1001/jamapsychiatry.2016.0637

Melnyk, B. Z., & Fineout-Overholt, E. (2015). Evidence-based practice in nursing & healthcare: A guide to best practice. Philadelphia: Wolters Kluwer Health.

Modesto-Lowe, V., Bojka, R., & Alvarado, C. (2018). Cannabis for peripheral neuropathy: The good, the bad and the unknown. Cleveland Clinic Journal of Medicine, 85(12), 943–949. https://doi.org/10.3949/ccjm.85a.17115 PMid:30526755 DOI: https://doi.org/10.3949/ccjm.85a.17115

Mojaverrostami, S., Bojnordi, M. N., Ghasemi-Kasman, M., Ebrahimzadeh, M. A., & Hamidabadi, H. G. (2018). A review of herbal therapy in multiple sclerosis. Advanced Pharmaceutical Bulletin, 8(4), 575–590. https://doi.org/10.15171/apb.2018.066 PMid:30607330; PMCid:PMC6311642 DOI: https://doi.org/10.15171/apb.2018.066

Mouhamed, Y., Vishnyakov, A., Qorri, B., Sambi, M., Frank, S. S., Nowierski, C. … Bhatti, U. (2018). Therapeutic potential of medical marijuana: An educational primer for health care proffesionals. Drug Healthcare and Patient Safety, 10, 45–66. https://doi.org/10.2147/DHPS.S158592 PMid:29928146; PMCid:PMC6001746 DOI: https://doi.org/10.2147/DHPS.S158592

Nacionalni inštitut za javno zdravje (NIJZ). (2015). Stanje na področju prepovedanih drog v Sloveniji. Ljubljana: Nacionalni inštitut za javno zdravje. Retreived January 20, 2019 from http://www.nijz.si/sites/www.nijz.si/files/publikacije-datoteke/nacionalno_porocilo_o_drogah_2015_0.pdf

Neubauer, D., Perkovič-Benedik, M., & Osredkar, D. (2019). Priporočila za uporabo kanabidiola in kanabinoidov (medicinske konoplje) v pediatriji: otroški nevrologiji. Ljubljana: Založba Univerze v Ljubljani, Medicinska fakulteta, Ustanova za otroško nevrologijo, Ljubljana. Retrieved August 15, 2019 from https:// www.institut-icanna.com/files/ULTIMO_Web.pdf

Noel, C. (2018). Evidence for the use of medical marijuana in psychiatric and neurologic disorders. Mental Health Clinician, 7(1), 29–38. https://doi.org/10.9740/mhc.2017.01.029 PMid:29955495; PMCid:PMC6007658 DOI: https://doi.org/10.9740/mhc.2017.01.029

Nolimal, D. (2015). Ali strah pred medicinsko konopljo res hromi zdravnike. Revija ISIS, 14(7), 20–26.

Owens, B. (2015). Drug development: The treasure chest. Nature, 525(7570), 6–8. https://doi.org/10.1038/525S6a PMid:26398738 DOI: https://doi.org/10.1038/525S6a

Pancer, J., & Dasgupta, K. (2019). Effects of cannabis use in youth and young adults with type 1 diabetes: The highs, the lows, the don't knows. Canadian Journal of Diabetes, 44(2), 121–127. https://doi.org/10.1016/j.jcjd.2019.05.001 PMid:31401053 DOI: https://doi.org/10.1016/j.jcjd.2019.05.001

Poli, P., Crestani, F., Salvadori, C., Valenti, I., & Sannino, C. (2017). Medical cannabis in patients with chronic pain: Effect on pain relief, pain dissability and psychological aspects: A prospective non randomized single arm clinical trial. Clinical Therapeutics, 169(3), 102–107.

Polit, D. F., & Beck, C. T. (2018). Essentials of nursing research: Appraising evidence for nursing practice (9th ed.) Philadelphia: Wolters Kluwer Health.

Predlog zakona o konoplji (2018). Retrieved January 20, 2019 from http://sksk.si/Predlog_zakona_o_konoplji.htm#_ Toc375388987

Robinson, R. (2015). Konopljin manifest: sto in en način, kako lahko konoplja reši svet. Visoko: Kiroja.

Scherma, M., Masia, P., Deidda, M., Fratta, W., Tanda, G., & Fadda, P. (2018). New perspectives on the use of cannabis in the treatment of psychiatric disorders. Medicines, 5(4), 107. https://doi.org/10.3390/medicines5040107 PMid:30279403; PMCid:PMC6313625 DOI: https://doi.org/10.3390/medicines5040107

Self, T. H., Shah, S. P., March, K. L., & Sands, C. W. (2016). Asthma associated with the use of cocaine, heroin and marijuana: A review of the evidence. Journal of Asthma, 54(7), 714–722. https://doi.org/10.1080/02770903.2016.1259420 PMid:27858495 DOI: https://doi.org/10.1080/02770903.2016.1259420

Stampanoni Bassi, M., Gilio, L., Dolcetti, E., Bruno, A., Buttari, F., Centonze, D., & Iezzi, E. (2018). Exploiting the multifaceted effects of cannabinoids on mood to boost their therapeutic use against anxiety and depression. Frontiers in Molecular Neuroscience, 11, 4–24. https://doi.org/10.3389/fnmol.2018.00424 PMid:30515077; PMCid:PMC6256035 DOI: https://doi.org/10.3389/fnmol.2018.00424

Stith, S., Vigil, J. M., Brockelman, F., Keeling, K., & Hall, B.(2018). Patient-reported symptom relief following medical cannabis consumption. Frontiers in Pharmacology, 9, 9–16. https://doi.org/10.3389/fphar.2018.00916 PMid:30210337; PMCid:PMC6121171 DOI: https://doi.org/10.3389/fphar.2018.00916

Turna, J., Patterson, B., & Van Ameringen, M. (2017). Is cannabis treatment for anxiety, mood and related disorders ready for prime time. Journal of Depression and Anxiety, 34(11), 1006–1017. https://doi.org/10.1002/da.22664 PMid:28636769 DOI: https://doi.org/10.1002/da.22664

Uredba o razvrstitvi prepovedanih drog. (2019). (Uradni list RS, št. 69/19 in 157/20) Retrieved April 22, 2021 from http://www.pisrs.si/Pis.web/ pregledPredpisa?id=URED7970

van Amsterdam, J., Vervloet, J., de Weert, G., Buwalda, V. J., Goudriaan, A. E., & van den Brink, W. (2018). Acceptance of pharmaceutical cannabis substitution by cannabis using patients with schizophrenia. Harm Reduction Journal, 15, Article 47. https://doi.org/10.1186/s12954-018-0253-7 PMid:30236118; PMCid:PMC6149068 DOI: https://doi.org/10.1186/s12954-018-0253-7

Welch, V., Petticrew, M., Tugwell, P., Moher, D., O'Neill, J., Waters, E. … the PRISMA-Equity Bellagio group (2012). PRISMA-Equity 2012 Extension: Reporting guidelines for systematic reviews with a focus onhealth equity. Public Library of Science Medicine, 9(10), Article e1001333. https://doi.org/10.1371/journal.pmed.1001333 PMid:23222917; PMCid:PMC3484052 DOI: https://doi.org/10.1371/journal.pmed.1001333

Zaheer, S., Kumar, D., Khan, M. T., Giyanwani, P. R., & Kiran, F. (2018). Epilepsy and cannabis: A literature review. Cureus, 10(9), 32–78. https://doi.org/10.7759/cureus.3278 PMid:30443449; PMCid:PMC6235654 DOI: https://doi.org/10.7759/cureus.3278

Zou, S., & Kumar, U. (2018). Cannabinoid receptors and the endocannabinoid system: Signaling and function in the central nervous system. International Journal of Molecular Sciences, 19(3), 8–33. https://doi.org/10.3390/ijms19030833 PMid:29533978; PMCid:PMC5877694 DOI: https://doi.org/10.3390/ijms19030833

Zuardi, A. W. (2008). Cannabidiol: From an inactive cannabinoid to a drug with wide spectrum of action. Brazilian Journal of Psychiatry, 30(3), 271–280. https://doi.org/10.1590/S1516-44462008000300015 PMid:18833429 DOI: https://doi.org/10.1590/S1516-44462008000300015

Zylla, D., Steele, G., Eklund, J., Mettner, J., & Arneson, T. (2018). Oncology clinicians and the Minnesota medical cannabis program: A survey on medical cannabis practice patterns, barriers to enrollment and educational needs. Cannabis and Cannabinoid Research, 3(1), 195–202. https://doi.org/10.1089/can.2018.0029 PMid:30426072; PMCid:PMC6225592 DOI: https://doi.org/10.1089/can.2018.0029

Čulić, A., Bregar, B., & Macur, M. (2021). Raba konoplje v medicinske namene: integrativni pregled literature. Obzornik zdravstvene nege, 55(4), 274–286. https://doi.org/10.14528/snr.2021.55.4.3063 DOI: https://doi.org/10.14528/snr.2021.55.4.3063

Prenosi

Objavljeno

2021-12-18

Kako citirati

Čulić, A., Bregar, B., & Macur, M. (2021). Raba konoplje v medicinske namene: integrativni pregled literature. Obzornik Zdravstvene Nege, 55(4), 274–286. https://doi.org/10.14528/snr.2021.55.4.3063

Številka

Rubrike

Pregledni znanstveni članek

Najbolj brani prispevki istega avtorja(jev)

1 2 > >>