Okužba s SARS-CoV-2 pri otrocih z oslabljeno imunostjo

pregled literature

Avtorji

  • Tatjana Stojnić Univerza v Mariboru, Fakulteta za zdravstvene vede, Žitna ulica 15, 2000 Maribor, Slovenija
  • Nataša Marčun Varda Univerzitetni klinični center Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenija https://orcid.org/0000-0003-0634-3576
  • Petra Klanjšek Univerza v Mariboru, Fakulteta za zdravstvene vede, Žitna ulica 15, 2000 Maribor, Slovenija https://orcid.org/0000-0003-3631-6691
  • Barbara Kegl Univerza v Mariboru, Fakulteta za zdravstvene vede, Žitna ulica 15, 2000 Maribor, Slovenija https://orcid.org/0000-0002-4749-4509

DOI:

https://doi.org/10.14528/snr.2026.60.1.3234

Ključne besede:

imunsko kompromitirani otroci, koronavirusna bolezen, potek okužbe

Povzetek

Uvod: Z virusom SARS-CoV-2 se lahko okužimo vsi. Pri otrocih z oslabljeno imunostjo obstaja večja možnost, da zbolijo za različnimi okužbami, tudi za boleznijo covid-19. Pomembno jih je pravočasno zdraviti, zlasti tiste z dodatnimi boleznimi. Namen raziskave je na podlagi pregleda literature raziskati potek bolezni covid-19 pri otrocih z oslabljeno imunostjo.
Metode: Pri pregledu znanstvene literature v angleškem jeziku je bila uporabljena deskriptivna metoda dela. Pregled literature je potekal v podatkovnih bazah PubMed, ScienceDirect, CINAHL in spletnem iskalniku Google Scholar. Za prikaz poteka pregleda smo uporabili smernice PRISMA. Podatki so predstavljeni opisno s povzemanjem skupnih značilnosti vključene literature. Vključeni članki so bili analizirani, sinteza pa je bila izvedena s pomočjo tematskega teoretičnega okvira.
Rezultati: V končno analizo je bilo vključenih 16 člankov. Identificirali smo: glavno temo – potek covida-19 pri otrocih z oslabljeno imunostjo; dve temi sekundarne ravni – (1) otroci z oslabljeno imunostjo in boleznijo covid-19, (2) diagnoza in zdravljenje covida-19 ter pet tem primarne ravni.
Diskusija in zaključek: Ugotovljeno je bilo, da so imeli otroci z oslabljeno imunostjo večinoma blag potek covida-19 in da zelo malo podatkov kaže na hud potek bolezni. Posledično smo opozorili na pomen higienskih ukrepov ter spremljanja zdravja in zdravstvenega stanja rizičnih skupin.

Prenosi

Podatki o prenosih še niso na voljo.

Literatura

Abuhammad, S., Alazzam, M., & Mukattash, T. (2021). The perception of nurses towards their roles during the COVID-19 pandemic. The International Journal of Clinical Practice, 75(4), Article e13919. https://doi.org/10.1111/ijcp.13919 PMID:33296522; PMCID:PMC7883258

Al-Dossary, R., Alamri, M. S., Almazan, J., Albaqawi, H. M., Al Hosis, K., Aljeldah, M., Aljohani, M., Aljohani, K., Almadani, N., Alrasheadi, B. A., & Falatah, R. (2020). Awareness, attitudes, prevention, and perceptions of COVID-19 outbreak among nurses in Saudi Arabia. International Journal of Environmental Research and Public Health, 17(21), Article 8269. https://doi.org/10.3390/ijerph17218269 PMID:33182352; PMCID:PMC7664870

BC Center for Disease Control. (2022, August 2). Children with immune compromise. http://www.bccdc.ca/healthinfo/diseases-conditions/covid-19/covid-19-and-children/children-with-immune-compromise

Bhayana, S., Kalra, M., & Sachdeva, A. (2022). Covid-19 in pediatric hematology-oncology and stem cell transplant patients: The spectrum of illness, complications and comparison of first two waves. Pediatric Hematology Oncology Journal, 7(3), 96–102. https://doi.org/10.1016/j.phoj.2022.05.003 PMCID:PMC9090776

Bisogno, G., Provenzi, M., Zama, D., Tondo, A., Meazza, C., Colombini, A., Galaverna, F., Compagno, F., Carraro, F., De Santis, R., Meneghello, L., Baretta, V., & Cesaro, S. (2020). Clinical characteristics and outcome of severe acute respiratory syndrome coronavirus 2 infection in Italian pediatric oncology patients: A study from the Infectious Diseases Working Group of the Associazione Italiana di Oncologia e Ematologia Pediatrica. Journal of the Pediatric Infectious Diseases Society, 9(5), 530–534. https://doi.org/10.1093/jpids/piaa088 PMID:32652521; PMCID:PMC7454778

Bridger, N. A., & Allen, U. D. (2019). Safe living strategies for the immunocompromised child. Paediatrics & Child Health, 24(4), Article 291. https://doi.org/10.1093/pch/pxz082 PMID:31239819; PMCID:PMC6587416

Cakmak, H. M. (2021). Management of Covid-19 disease in pediatric oncology patients. In V. Kumar (Ed.), SARS-CoV-2 Origin and COVID-19 Pandemic Across the Globe, Article 129. https://www.intechopen.com/chapters/78445

Chowdhoury, S. R., Biswas, H. S., Raut, S., Bhakta, S., Roy, A., Banerjee, S., & Nandi, M. (2021). Pediatric oncology patients and COVID-19: An experience from the tertiary COVID care facility in Eastern India: A prospective observational study. Indian Journal of Medical and Paediatric Oncology, 42(02), 130–134. https://doi.org/10.1055/s-0041-1732814

Čamernik, M. (2014). Imunske bolezni in zaščita otrok z oslabljenim imunskim sistemom pred okužbo. Slovenska Pediatrija, 21(1), 84–90.

De Souza, T. H., Nadal, J. A., Nogueira, R. J., Pereira, R. M., & Brandão, M. B. (2020). Clinical manifestations of children with COVID-19: A systematic review. Pediatric Pulmonology, 55(8), 1892–1899. https://doi.org/10.1002/ppul.24885 PMID:32492251; PMCID:PMC7300659

Dolan, S. A., Mulcahy Levy, J., Moss, A., Pearce, K., Butler, M., Jung, S., Dominguez, S. R., Mwangi, E., Maloney, K., & Rao, S. (2021). SARS-CoV-2 persistence in immunocompromised children. Pediatric Blood & Cancer, 68(12), Article e29277. https://doi.org/10.1002/pbc.29277 PMID:34453477; PMCID:PMC8661864

El Dannan, H., Al Hassani, M., & Ramsi, M. (2020). Clinical course of COVID-19 among immunocompromised children: A clinical case series. BMJ Case Reports CP, 13(10), Article e237804. https://doi.org/10.1136/bcr-2020-237804 PMID:33130585; PMCID:PMC10577704

Esposito, S., Prada, E., Lelii, M., & Castellazzi, L. (2015). Immunization of children with secondary immunodeficiency. Human Vaccines & Immunotherapeutics, 11(11), 2564–2570. https://doi.org/10.1080/21645515.2015.1039208 PMID:26176360; PMCID:PMC4685680

Fawaz, M., Anshasi, H., & Samaha, A. (2020). Nurses at the front line of COVID-19: Roles, responsibilities, risks, and rights. The American Journal of Tropical Medicine and Hygiene, 103(4), 1341–1342. https://doi.org/10.4269/ajtmh.20-0650 PMID:32783796; PMCID:PMC7543802

Filippatos, F., Tatsi, E. B., & Michos, A. (2023). Immunology of multisystem inflammatory syndrome after COVID-19 in children: A review of the current evidence. International Journal of Molecular Sciences, 24(6), Article 5711. https://doi.org/10.3390/ijms24065711 PMID:36982783; PMCID:PMC10057510

Freeman, M. C., Rapsinski, G. J., Zilla, M. L., & Wheeler, S. E. (2021). Immunocompromised seroprevalence and course of illness of SARS-CoV-2 in one pediatric quaternary care center. Journal of the Pediatric Infectious Diseases Society, 10(4), 426–431. https://doi.org/10.1093/jpids/piaa123 PMID:33049042; PMCID:PMC7665604

Gampel, B., Troullioud Lucas, A. G., Broglie, L., Gartrell-Corrado, R. D., Lee, M. T., Levine, J., Orjuela-Grimm, M., Satwani, P., Glade-Bender, J., & Roberts, S. S. (2020). COVID-19 disease in New York City pediatric hematology and oncology patients. Pediatric Blood & Cancer, 67(9), Article e28420. https://doi.org/10.1002/pbc.28420 PMID:32588957; PMCID:PMC7361160

Goss, M. B., Galván, N. T. N., Ruan, W., Munoz, F. M., Brewer, E. D., O’Mahony, C. A., Melicoff-Portillo, E., Sunny, K. S., Wallisch, M. A., Fleseriu, S., Kupfer, J. M., Hornung, B., Mulay, S., & Goss, J. A. (2021). The pediatric solid organ transplant experience with COVID-19: An initial multi-center, multi-organ case series. Pediatric Transplantation, 25(3), Article e13868. https://doi.org/10.1111/petr.13868 PMID:32949098; PMCID:PMC7537006

Goldschmidt, K. (2021). Covid-19 vaccines for children: The essential role of the pediatric nurse. Journal of Pediatric Nursing, 57, Article 96. https://doi.org/10.1016/j.pedn.2020.12.004 PMID:33342640; PMCID:PMC7732219

Götzinger, F., Santiago-García, B., Noguera-Julián, A., Lanaspa, M., Lancella, L., Calò Carducci, F. I. C., Gabrovska, N., Velizarova, S., Prunk, P., Osterman, V., Krivec, U., Lo Vecchio, A., Shingadia, D., Soriano-Arandes, A., Melendo, S., Lanari, M., Pierantoni, L., Wagner, N., L’Huillier, A. G., … Riordan, A. (2020). COVID-19 in children and adolescents in Europe: A multinational, multicentre cohort study. The Lancet Child & Adolescent Health, 4(9), 653–661. https://doi.org/10.1016/S2352-4642(20)30177-2 PMID:32593339

Hammad, M., Shalaby, L., Sidhom, I., Sherief, N., Abdo, I., Soliman, S., Madeny, Y., Hassan, R., Elmeniawy, S., Khamis, N., Zaki, I., Mansour, T., El-Ansary, M. G., Al-Halfawy, A., Abouelnaga, S., & Elhaddad, A. (2021). Management and outcome of coronavirus disease 2019 (COVID-19) in pediatric cancer patients: A single centre experience from a developing country. Clinical Lymphoma Myeloma and Leukemia, 21(11), e853–e864. https://doi.org/10.1016/j.clml.2021.07.025 PMID:34420893; PMCID:PMC8312090

Hassan, S. A., Sheikh, F. N., Jamal, S., Ezeh, J. K., & Akhtar, A. (2020). Coronavirus (COVID-19): A review of clinical features, diagnosis, and treatment. Cureus, 12(3), Article e7355. https://doi.org/10.7759/cureus.7355

Hrusak, O., Kalina, T., Wolf, J., Balduzzi, A., Provenzi, M., Rizzari, C., Rives, S., del Pozo Carlavilla, M., Alonso, M. E. V., Domínguez-Pinilla, N., Bourquin, J. P., Schmiegelow, K., Attarbaschi, A., Grillner, P., Mellgren, K., van der Werff ten Bosch, J., Pieters, R., Brozou, T., Borkhardt, A., … Schrappe, M. (2020). Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. European Journal of Cancer, 132, 11–16. https://doi.org/10.1016/j.ejca.2020.03.021 PMID:32305831; PMCID:PMC7141482

Infection Control Today. (2021, April 28). COVID-19 underscores nurses’ role in infection prevention. https://www.infectioncontroltoday.com/view/covid-19-underscores-nurses-role-in-infection-prevention

Kamdar, K. Y., Kim, T. O., Doherty, E. E., Pfeiffer, T. M., Qasim, S. L., Suell, M. N., Yates, A. M., & Blaney, S. M. (2021). COVID-19 outcomes in a large pediatric hematology-oncology center in Houston, Texas. Pediatric Hematology and Oncology, 38(8), 695–706. https://doi.org/10.1080/08880018.2021.1924327 PMID:34032552

Kuczborska, K., & Książyk, J. (2021). Prevalence and course of SARS-CoV-2 infection among immunocompromised children hospitalised in the tertiary referral hospital in Poland. Journal of Clinical Medicine, 10(19), Article 4556. https://doi.org/10.3390/jcm10194556 PMID:34640570; PMCID:PMC8509507

Madhusoodhan, P. P., Pierro, J., Musante, J., Kothari, P., Gampel, B., Appel, B., Levy, A., Tal, A., Hogan, L., Sharma, A., Feinberg, S., Kahn, A., Pinchinat, A., Bhatla, T., Glasser, C. L., Satwani, P., Raetz, E. A., Onel, K., Carroll, W. L., … Parsons, S. K. (2021). Characterization of COVID-19 disease in pediatric oncology patients: The New York-New Jersey regional experience. Pediatric Blood & Cancer, 68(3), Article e28843. https://doi.org/10.1002/pbc.28843 PMID:33338306; PMCID:PMC7883045

Meena, J. P., Kumar Gupta, A., Tanwar, P., Ram Jat, K., Mohan Pandey, R., & Seth, R. (2021). Clinical presentations and outcomes of children with cancer and COVID-19: A systematic review. Pediatric Blood & Cancer, 68(6), Article e29005. https://doi.org/10.1002/pbc.29005 PMID:33719167; PMCID:PMC8251055

Melnyk, B. M., & Fineout-Overholt, E. (2019). Evidence-based practice in nursing and healthcare: A guide to best practice (4th ed.). Lippincott Williams & Wilkins.

Millen, G. C., Arnold, R., Cazier, J. B., Curley, H., Feltbower, R. G., Gamble, A., Glaser, A. W., Grundy, R. G., Lee, L. Y. W., McCabe, M. G., Phillips, R. S., Stiller, C. A., Várnai, C., & Kearns, P. R. (2021). Severity of COVID-19 in children with cancer: Report from the United Kingdom Paediatric Coronavirus Cancer Monitoring Project. British Journal of Cancer, 124(4), 754–759. https://doi.org/10.1038/s41416-020-01181-0 PMID:33299130; PMCID:PMC7884399

Moher, D., Shamseer, L., Clarke, M., Ghersi, D., Liberati, A., Petticrew, M., Shekelle, P., Stewart, L. A., & PRISMA-P Group. (2015). Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Systematic Reviews, 4(1), Article 1. https://doi.org/10.1186/2046-4053-4-1 PMID:25554246; PMCID:PMC4320440

Mukkada, S., Bhakta, N., Chantada, G. L., Chen, Y., Vedaraju, Y., Faughnan, L., Homsi, M. R., Muniz-Talavera, H., Ranadive, R., Metzger, M., Friedrich, P., Agulnik, A., Jeha, S., Lam, C., Dalvi, R., Hessissen, L., Moreira, D. C., Santana, V. M., Sullivan, M., … Raimbault, S. (2021). Global characteristics and outcomes of SARS-CoV-2 infection in children and adolescents with cancer (GRCCC): A cohort study. The Lancet Oncology, 22(10), 1416–1426. https://doi.org/10.1016/S1470-2045(21)00454-X PMID:34454651

Nearchou, F., & Flinn, C. (2024). The impact of COVID-19 on children and adolescents with chronic illness. In G. J. G. Asmundson, S. Taylor, & B. J. Cox (Eds.), The COVID-19 aftermath (Vol. 1457, pp. 385–399). Springer. https://doi.org/10.1007/978-3-031-61939-7_22

Nikolopoulou, G. B., & Maltezou, H. C. (2021). COVID-19 in children: Where do we stand. Archives of Medical Research, 53(1), 1–8. https://doi.org/10.1016/j.arcmed.2021.07.002 PMID:34311990; PMCID:PMC8257427

Olivé-Cirera, G., Fonseca, E., Cantarín-Extremera, V., Vázquez-López, M., Jiménez-Legido, M., González-Álvarez, V., Ribeiro-Constante, J., Camacho-Salas, A., Martí, I., Cancho-Candela, R., Martínez-González, M. J., Saiz, A., Armangué, T., … Armangué, T. (2022). Impact of COVID-19 in immunosuppressed children with neuroimmunologic disorders. Neurology-Neuroimmunology Neuroinflammation, 9(1), Article e1101. https://doi.org/10.1212/NXI.0000000000001101 PMID:34759018; PMCID:PMC8587734

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., McGuinness, … Moher, D. (2021). The PRISMA 2020 statement: An updated guideline for reporting systematic reviews. BMJ, 372, Article n71. https://doi.org/10.1136/bmj.n71 PMID:33782057; PMCID:PMC8005924

Pérez-Martinez, A., Guerra-García, P., Melgosa, M., Frauca, E., Fernandez-Camblor, C., Remesal, A., & Calvo, C. (2021). Clinical outcome of SARS-CoV-2 infection in immunosuppressed children in Spain. European Journal of Pediatrics, 180(3), 967–971. https://doi.org/10.1007/s00431-020-03793-3 PMID:32860101; PMCID:PMC7455510

Pittet, L. F., & Posfay-Barbe, K. M. (2021). Vaccination of immune compromised children: An overview for physicians. European Journal of Pediatrics, 180(7), 2035–2047. https://doi.org/10.1007/s00431-021-03997-1 PMID:33665677; PMCID:PMC8195953

Polit, D. F., & Beck, C. T. (2021). Nursing research: Generating and assessing evidence for nursing practice (11th ed.). Wolters Kluwer Health, Lippincott Williams and Wilkins.

Rao, S. K., Kumar, A., Prasad, R., Gupta, V., & Mishra, O. P. (2021). Clinical profile and outcome of COVID-19 among immunocompromised children. Indian Pediatrics, 58(7), 686–687. https://doi.org/10.1007/s13312-021-2267-6 PMID:34315835; PMCID:PMC8339160

She, J., Liu, L., & Liu, W. (2020). COVID-19 epidemic: Disease characteristics in children. Journal of Medical Virology, 92(7), 747–754. https://doi.org/10.1002/jmv.25807 PMID:32232980; PMCID:PMC7228385

Singer, P. S., Sethna, C., Molmenti, E., Fahmy, A., Grodstein, E., Castellanos-Reyes, L., Fassano, J., & Teperman, L. (2021). COVID-19 infection in a pediatric kidney transplant population: A single-center experience. Pediatric Transplantation, 25(4), Article e14018. https://doi.org/10.1111/petr.14018 PMID:33813782; PMCID:PMC8250351

Sullivan, M., Bouffet, E., Rodriguez-Galindo, C., Luna-Fineman, S., Khan, M. S., Kearns, P., Mechinaud, F., Graeber, A., Kohler, J., Jähnichen, A., Friedrich, P., Ribeiro, R. C., Ribeiro, R. M., Baruchel, A., Voss, S., Gupta, S., Sullivan, N., Schrappe, M., Rennie, K. L., … Heuvel-Eibrink, M. V. D. (2020). The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global. Pediatric Blood & Cancer, 67(7), Article e28409. https://doi.org/10.1002/pbc.28409 PMID:32400924; PMCID:PMC7235469

Thomas, J., & Harden, A. (2008). Methods for the thematic synthesis of qualitative research in systematic reviews. BMC Medical Research Methodology, 8(1), 1–10. https://doi.org/10.1186/1471-2288-8-45 PMID:18616818; PMCID:PMC2478656

Widiasih, R., Ermiati, Emaliyawati, E., Hendrawati, S., Susanti, R. D., Sutini, T., & Sari, C. W. M. (2021). Nurses’ actions to protect their families from COVID-19: A descriptive qualitative study. Global Qualitative Nursing Research, 8, Article 23333936211014851. https://doi.org/10.1177/23333936211014851 PMID:33997120; PMCID:PMC8110897

Woodruff, R. C., Campbell, A. P., Taylor, C. A., Chai, S. J., Kawasaki, B., Meek, J., & Havers, F. (2022). Risk factors for severe COVID-19 in children. Pediatrics, 149(1), Article e2021053418. https://doi.org/10.1542/peds.2021-053418 PMID:34935038; PMCID:PMC9213563

World Health Organization. (2021, May 13). Coronavirus disease (COVID-19). https://www.who.int/emergencies/diseases/novel-coronavirus-2019/question-and-answers-hub/q-a-detail/coronavirus-disease-covid-19

Zehra, C., & Gulendam, K. (2021). Children with chronic disease during COVID-19 pandemic and nurses' roles. International Journal of Caring Sciences, 14(3), 2058–2065. https://www.internationaljournalofcaringsciences.org

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Objavljeno

24.03.2026

Kako citirati

Stojnić, T. ., Marčun Varda, N., Klanjšek, P., & Kegl, B. (2026). Okužba s SARS-CoV-2 pri otrocih z oslabljeno imunostjo: pregled literature. Obzornik Zdravstvene Nege, 60(1), 35–45. https://doi.org/10.14528/snr.2026.60.1.3234

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