Oxytocin for labour induction or augmentation as a risk factor for autism: systematic literature review
DOI:
https://doi.org/10.14528/snr.2017.51.2.154Keywords:
oxytocin, labour, autism, autism spectrum disorderAbstract
Introduction: Some studies have shown a potential association between oxytocin use during labour and autism spectrum disorder in children (ASD). We performed a systematic review of recent studies examining this association. Methods: Boolean operators (AND/OR) were used to search MEDLINE using the following search criteria: Autistic Disorder or Autism Spectrum Disorder or Autism and Labour Induction or Labour Augmentation. Articles published in English in 2013 or later were considered. Additional studies were identified by reviewing citations. Only studies conducted on people were included. Studies not accounting for potential confounding factors were excluded. Results: Four retrospective cohort studies met the inclusion criteria. One showed an association between labour induction and augmentation and ASD, one showed a weak association between labour augmentation in boys and ASD, and one showed no association between labour induction or augmentation and ASD. The largest study showed a weak association between labour induction and ASD, which was not significant when siblings were analyzed separately. Discussion and conclusions: Recently published studies do not support the hypothesis of a causal relationship between oxytocin use during labour and ASD. Benefits of medically indicated induction or augmentation of labour outweigh the theoretical risk of ASD.
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American College of Obstetricians and Gynecologists, 2009. ACOG Practice Bulletin No. 107: Induction of labour. Obstetrics & Gynecology, 114, pp. 386–397. https://doi.org/10.1097/AOG.0b013e3181b48ef5 PMid:19623003
Autism Speaks, 2013. Available at: http://www.autismspeaks.org/science/science-news/study-links-inducingaugmenting-labor-modestly-higher-autism-risk. [27.3.2017].
Bilder, D., Pinborough-Zimmerman, J., Miller, J. & McMahon, W., 2009. Prenatal, perinatal, and neonatal factors associated with Autism Spectrum Disorders. Pediatrics, 123(5), pp. 1293–1300. https://doi.org/10.1542/peds.2008-0927 PMid:19403494
Burstyn, I., Sithole, F. & Zwaigenbaum, L., 2010. Autism spectrum disorders, maternal characteristics and obstetric complications among singletons born in Alberta, Canada. Chronic Diseases in Canada, 30(4), pp. 125–134.
Clark, E., Bilder, D., Varner, M., Esplin, M., Coon, H. & Bakian, A., 2015. Autism spectrum disorder and induced/augmented labor: epidemiologic analysis of a utah cohort. American Journal of Obstetrics & Gynecology, 212, pp. S4–S5. https://doi.org/10.1016/j.ajog.2014.10.037
Decoded Pregnancy, 2013. Available at: http://decodedpregnancy.com/induced-labor-does-exposure-to-pitocin-increase-your-babys-risk-for-autism/2468/. [27.3.2017].
Disability Scoop, 2013. Available at: https://www.disabilityscoop.com/2013/08/13/inducing-labor-autism-risk/18506/ [27.3.2017].
Durkin, M.S., Maenner, M.J., Newschaffer, C.J., Lee, L.C., Cunniff, C.M., Daniels, J.L., et al., 2008. Advanced parental age and the risk of Autism Spectrum Disorder. American Journal of Epidemiology, 168(11), pp. 1268–1276. https://doi.org/10.1093/aje/kwn250 PMid:18945690; PMCid:PMC2638544
Ebstein, R.P., Israel, S., Lerer, E., Uzefovsky, F., Shalev, I., Gritsenko, I., et al., 2009. Arginine vasopressin and oxytocin modulate human social behavior. Annals of the New York Academy of Sciences, 1167, pp. 87–102. https://doi.org/10.1111/j.1749-6632.2009.04541.x PMid:19580556
Gardener, H., Spiegelman, D. & Buka, S.L., 2009. Prenatal risk factors for autism: comprehensive meta-analysis. The British Journal of Psychiatry, 195(1), pp. 7–14. https://doi.org/10.1192/bjp.bp.108.051672 PMid:19567888; PMCid:PMC3712619
Glasson, E.J., Bower, C., Petterson, B., Klerk, N., Chaney, G.& Hallmayer, J.F., 2004. Perinatal factors and the development of Autism. Archives of Genneral Psychiatry, 61(6), pp. 618–627. https://doi.org/10.1001/archpsyc.61.6.618 PMid:15184241
Gregory, S.G., Connelly, J.J., Towers, A.J., Johnson, J., Biscocho, D., Markunas, C.A., et al., 2009. Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Medicine, 62(7), pp. 1–13. https://doi.org/10.1186/1741-7015-7-62
Gregory, S.G., Anthopolos, R., Osgood, C.E., Grotegut, C.A. & Miranda, M.L., 2013. Association of Autism with induced or augmented childbirth in North Carolina Birth Record (1990–1998) and Education Research (1997–2007) Databases. JAMA Pediatrics, 167(10), pp. 959–966. https://doi.org/10.1001/jamapediatrics.2013.2904 PMid:23938610
Hultman, C.M., Sparen, P. & Cnattingius, S., 2002. Perinatal risk factors for infantile Autism. Epidemiology, 13(4), pp. 417–423. https://doi.org/10.1097/00001648-200207000-00009 PMid:12094096
Larsson, H.J., Eaton, W.W., Madsen, K.M., Vestergaard, M., Olesen, A.V., Agerbo, E., et al., 2005. Risk factors for Autism: perinatal factors, parental psychiatric history, and socioeconomic status. American Journal of Epidemiology, 161(10), pp. 916–951. https://doi.org/10.1093/aje/kwi123 PMid:15870155
Levy, S.E., Mandell, D.S. & Schultz, R.T., 2009. Autism. The Lancet, 374(9701), pp. 1627–1638. https://doi.org/10.1016/S0140-6736(09)61376-3
Macedoni-Lukšič, M., 2006. Spekter avtistične motnje. In: C. Kržišnik & T. Battelino, eds. Novosti v otroški gastroenterologiji: izbrana poglavja iz pediatrije 18. Ljubljana: Univerza v Ljubljani, Medicinska fakulteta, Katedra za pediatrijo, pp. 115–126.
Macedoni-Lukšič, M., Jurišič, B.D., Rovšek, M., Melanšek, V., Potočnik, N.D., Bužan, V., et al., 2009. Smernice za celostno obravnavo oseb s spektroavtističnimi motnjami. Ljubljana: Ministrstvo za zdravje, pp. 11–29.
Oberg, A.S., D'Onofrio, B.M., Rickert, M.E., Hernandez-Diaz, S., Ecker, J.L., Almqvist, C., et al., 2016. Association of labour induction with offspring risk of Autism Spectrum Disorders. JAMA Pediatrics, 170(9), pp. 170–179. https://doi.org/10.1001/jamapediatrics.2016.0965 PMid:27454803
Park, H.R., Lee, J.M., Moon, H.E., Lee, D.S., Kim, B.N., Kim, J., et al., 2016. A short review on the current understanding of Autism Spectrum Disorders. Experimental Neurobiology, 25(1), pp. 1–13. https://doi.org/10.5607/en.2016.25.1.1 PMid:26924928 PMCid:PMC4766109
Porodna Hiša, 2011. Available at: http://visfeminea.blogspot.si/2011/02/stranski-ucinki-umetnih-popadkov.html [27.3.2017].
PRISMA, 2017. Preferred reporting items for systematic reviews and meta-analyses (PRISMA). Available at: http://prisma-statement.org/Default.aspx [28.2.2017].
Smallwood, M., Sareen, A., Baker, E., Hannusch, R., Kwessi, E. & Williams, T., 2016. Increased risk of Autism development in children whose mothers experienced birth complications or received labour and delivery drugs. ASN Neuro, 8(4). pp. 1–6. https://doi.org/10.1177/1759091416659742 PMid:27511908 PMCid:PMC4984315
Verdenik, I., Novak Antolič, Ž., & Zupan, J., 2013. Perinatologia Slovenica II: slovenski perinatalni rezultati za obdobje 2002–2011. Ljubljana: Združenje za perinatalno medicine SZD, Ginekološka klinika, UKC Ljubljana, pp. 11–16.
Weisman, O., Agerbo, E., Carter, C.S., Harris, J.C., Uldbjerg, N., Henriksen, T.B., et al., 2015. Oxytocin-augmented labour and risk for autism in males. Behavioural Brain Research, 284, pp. 207–212. https://doi.org/10.1016/j.bbr.2015.02.028 PMid:25707712
Williams, E., Thomas, K., Sidebotham, H. & Emond, A., 2008. Prevalence and characteristics of autistic spectrum disorders in the ALSPAC cohort. Developmental Medicine & Child Neurology, 50(9), pp. 672–677. https://doi.org/10.1111/j.1469-8749.2008.03042.x PMid:18754916
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